ACTH-CYTOKINE ASSOCIATIONS IN THE «SKIN WINDOW» EXUDATES IN ATOPIC DERMATITIS
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Abstract
Currently, atopic dermatitis is one of the most common chronic recurrent skin diseases, and, furthermore, the first manifestation of atopy. The pathogenesis of this disease has not been fully studied, it is multifaceted, since it is a pathogenic combination of the tridirectional interaction between the nervous, endocrine and immune systems both at the whole body level and level of the largest barrier organ, which is the skin. In addition, genetic, epigenetic, and environmental factors contribute to atopic dermatitis pathogenesis significantly. The use of the «skin window» model, values of adrenocorticotropic hormone (ACTH) and inflammasome associated cytokines were determined in skin exudates.
19 patients with exacerbation forms of atopic dermatitis and 25 volunteers were examined. It has been revealed that in the clinical group of patients, the values of ACTH was significantly reduced compared to the control group, whereas the content of IL-1ß, IL-18, IL-6, and TNF-α in the exudates of the «skin window» in atopic dermatitis essentially exceeded control parameters.
The data obtained illustrate the dysregulation condition between the endocrine and immune systems at the skin level reduce the anti-inflammatory potential of the skin and increase pro-inflammatory activity. Cytokine overproduction is related to pro-inflammatory cytokines, which are essential for inflammasomes activation in the skin.
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