ОТЛИЧИТЕЛЬНЫЕ ЧЕРТЫ ИНФЛАММАСОМЫ NLRP1 ПРИ АТОПИЧЕСКИХ АЛЛЕРГИЯХ


Загрешенко Д.С., Климов А.В., Климов В.В., Кошкарова Н.С., Найдина О.А., Цыплина Е.Ю.

Аннотация


Обзорная статья посвящена инфламмасоме NLRP1, которая была открыта раньше других, но оказалась наименее исследованной. Возникновение инфламмасомы в клетках-контейнерах, относящихся к естественному иммунитету – это раннее событие, которое предшествует развитию любого воспалительного процесса, включая аллергическое воспаление. В обзорной статье дана характеристика структуры, основных активационных сигналов, процесса активации NLRP1 и связи с болезнями человека с акцентом на такие атопии, как атопический дерматит, аллергический ринит и аллергическую астму, а также даётся обоснование ассоциаций мутаций в гене сенсора NLRP1 и генах, соответствующих предрасположенности к атопии. Также отмечается связь NLRP1 со злокачественными новообразованиями.


Ключевые слова


атопии; инфламмасома NLRP1; пироптоз; IL-1beta; IL-18; IL-33

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Литература


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