Main Article Content
Abstract
Amyotrophic lateral sclerosis (ALS) is rare neurodegenerative disease that needs prolonged respiratory therapy. Ventilator respiratory support is strongly requested for intensive care in different critical illnesses, but it is associated with high risk of specific complications. Latter could rarely be avoided especially in cases of prolong mechanically ventilation that provided in cases of central nervous system injury, major trauma, persisting organ dysfunction etc. Despite the fact of incurable loss of spontaneous breathing in patients with ALS, logistic path of outpatient palliative care provision is absent. Nonetheless outpatient individual intensive care, for respiratory tract particularly, makes possible to avoid serious ventilator-associated adverse events for a long period.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Al-Chalabi A, Hardiman O. The epidemiology of ALS: a conspiracy of genes, environment and time. Nature Reviews Neurology. 2013; 9(11): 617-628
Salameh J, Brown RJr, Berry J. Amyotrophic Lateral Sclerosis: Review. Seminars Neurology. 2015; 35: 469-476
Bensimon G, Lacomblez L, Delumeau J, Bejuit R. A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. J of Neurol. 2002; 249(5): 609-615. doi: 10.1007/s004150200071
Cappella M, Ciotti C, Cohen-Tannoudji M, Biferi MG. Gene Therapy for ALS – a Perspective. Int J Mol Sci. 2019; 20(18): 4388. https://doi.org/10.3390/ijms20184388
Peña-López Y, Ramirez-Estrada S, Eshwara V, Rello J. Limiting ventilator-associated complications in ICU intubated subjects: strategies to prevent Ventilator-associated events and improve outcomes. Expert Rev Respir Med. 2018; 12(12): 1037-1050. doi: 10.1080/17476348.2018.1549492
Spalding D, Cripps M, Minshall C. Ventilator-Associated Pneumonia: New Definitions. Critical Care Clinics. 2017; 33(2): 277-292. doi: 10.1016/j.ccc.2016.12.009
Van Vught L, Klowenberg P, Spitoni C, Scicluna BP, Wiewel MA, Horn J et al. Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis. JAMA. 2016; 315(14): 1469-1479. doi: 10.1001/jama.2016.2691
Klompas M. What is new in the prevention of nosocomial pneumonia in the ICU? Curr Opin Crit Care. 2017; 23(5): 378-384. doi: 10.1097/MCC.0000000000000443
Fasano A, Fini N, Ferraro D, Ferri L, Vinceti M, Mandrioli J. Percutaneous endoscopic gastrostomy, body weight loss and survival in amyotrophic lateral sclerosis: a population-based registry study. Amyotroph Lateral Scler Frontotemporal Degener. 2017; 18(3-4): 233-242. doi: 10.1080/21678421.2016.1270325