L-ANTITRYPSIN DEFICIENCY. THE ALGORITHM OF ACTIONS IN MAKING A DIAGNOSIS AND DETERMINING THE TACTICS OF PATIENT MANAGEMENT

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Section:
LECTURES
Published:
2025-09-24
DOI:
https://doi.org/10.24412/2687-0053-2025-3-82-85

Main Article Content

Надежда Григорьевна Ганюкова
S.V. Belyaev Kuzbass Regional Clinical Hospital, Kemerovo
http://orcid.org/0000-0001-8407-7379
Людмила Сергеевна Гофман
S.V. Belyaev Kuzbass Regional Clinical Hospital, Kemerovo
http://orcid.org/0000-0001-6867-5694
Марина Геннадьевна Якушенко
S.V. Belyaev Kuzbass Regional Clinical Hospital, Kemerovo
Светлана Ивановна Елгина
Kemerovo State Medical University
Елена Владимировна Рудаева
Kemerovo State Medical University
Кира Борисовна Мозес
Kemerovo State Medical University

Abstract

The article presents a clinical lecture on alpha-1-antitrypsin (A1AT) deficiency, a genetically determined disease caused by A1AT deficiency in blood serum and manifested in the form of chronic obstructive pulmonary disease, emphysema, liver and vascular damage. Its pathophysiology, diagnosis, treatment and prevention.

Keywords

alpha-1-antitrypsin, etiology, pathogenesis, diagnosis, treatment

Author Biographies

Надежда Григорьевна Ганюкова,
candidate of medical sciences, pulmonologist of the pulmonology department
Людмила Сергеевна Гофман,
head of the pulmonology department
Марина Геннадьевна Якушенко,
pulmonologist, pulmonology department
Светлана Ивановна Елгина,
doctor of medical sciences, docent, professor of the department of obstetrics and gynecology named after G.A. Ushakova
Елена Владимировна Рудаева,
candidate of medical sciences, docent, docent of the G.A. Ushakova department of obstetrics and gynecology
Кира Борисовна Мозес,
assistant of the department of polyclinic therapy and nursing

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
© Надежда Григорьевна Ганюкова, Людмила Сергеевна Гофман, Марина Геннадьевна Якушенко, Светлана Ивановна Елгина, Елена Владимировна Рудаева, Кира Борисовна Мозес, 2025


Creative Commons License  This work is licensed under a Creative Commons Attribution 4.0 License.

How to Cite

Ганюкова, Н. Г., Гофман, Л. С., Якушенко, М. Г., Елгина, С. И., Рудаева, Е. В., & Мозес, К. Б. (2025). L-ANTITRYPSIN DEFICIENCY. THE ALGORITHM OF ACTIONS IN MAKING A DIAGNOSIS AND DETERMINING THE TACTICS OF PATIENT MANAGEMENT. Medicine in Kuzbass, 24(3), 82-85. https://doi.org/10.24412/2687-0053-2025-3-82-85

References

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Alí-Munive A, Leidy P, Proaños NJ, Pedrozo-Pupo J, Giraldo A, Cano D, et al. Prevalence of genetic mutations in alpha-1 antitrypsin deficiency (aatd) in patients with chronic obstructive pulmonary disease in Colombia. BMC Pulm Med. 2023; 23(1): 156. doi: 10.1186/s12890-023-02453-0

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Fairbanks KD, Tavill AS. Liver disease in alpha 1-antitrypsin deficiency: a review. Am J Gastroenterol. 2008; 103(8): 2136-2142. doi: 10.1111/j.1572-0241.2008.01955.x

American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003; 168(7): 818-900. doi: 10.1164/rccm.168.7.818

Franciosi AN, Ralph J, O'Farrell NJ, Buckley C, Gulmann C, O'Kane M, et al. Alpha-1 antitrypsin deficiency-associated panniculitis. J Am Acad Dermatol. 2022; 87(4): 825-832. doi: 10.1016/j.jaad.2021.01.074

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