POLYMORPHISM C634G OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR A GENE IN PATIENTS WITH DIABETIC FOOT IN THE TRANS-BAIKAL TERRITORY
Main Article Content
Abstract
Purpose of the work – to study the frequency of occurrence of genotypes and alleles of the C634G polymorphism of the VEGFA gene in patients with a mixed form of DFS and in the control group living in the Trans-Baikal Territory.
Materials and methods. The study involved 199 patients with a mixed form of diabetic foot syndrome and 100 practically healthy people, in whom the frequency of occurrence of genotype variants and the C634G polymorphism alley of the vascular endothelial growth factor A gene was studied by polymerase chain reaction.
Results. The G/G genotype was 1.4 times more likely to be registered in the group with the development of diabetic foot syndrome. The frequency of the G/C genotype did not differ in the studied groups of heterozygotes. The C/C genotype in the group of patients was registered 2.9 times less frequently than in the control group. With the development of diabetic foot syndrome, allele G was detected 1.9 times less than in the control group. Allele C in the group of patients was 2.4 times more common than in the control group.
Conclusion. The relationship between the variants of the genotypes of the C634G polymorphism of the VEGFA gene and the development of DFS in the population of the Trans-Baikal Territory was revealed.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Artikova DM, Artikov AF. Epidemiology, etiology and pathogenesis of diabetic foot syndrome. Academic research in educational sciences. 2023; 1: 248-254. Russian (Артикова Д.М., Артиков А.Ф. Эпидемиология, этиология и патогенез синдрома диабетической стопы //Academic research in educational sciences. 2023. № 1. С. 248-254)
Davlatov S.S. Clinical, immuno-microbiological aspects of the development of diabetic foot syndrome (literature review). Dostizheniya nauki i obrazovaniya. 2022; 4(84): 21-26. Russian (Давлатов С.С. Клинические, иммуно-микробиологические аспекты развития синдрома диабетической стопы (обзор литературы) //Достижения науки и образования. 2022. Т. 4, № 84. С. 21-26)
Bardyugov PS, Parshikov MV. Foot deformities in patients with diabetic foot disease (literature review). Genij ortopedii. 2022; 28(3): 452-458. Russian (Бардюгов П.С., Паршиков М.В. Деформации стоп у пациентов с синдромом диабетической стопы (обзор литературы) //Гений ортопедии. 2022. Т. 28, № 3. С. 452-458.) doi: 10.18019/1028-4427-2022-28-3-452-458
Chang M, Nguyen TT. Strategy for Treatment of Infected Diabetic Foot Ulcers. Acc Chem Res. 2021; 54(5): 1080-1093. doi: 10.1021/acs.accounts.0c00864
Terekhov A.G., Klyueva E.G. Current understanding of the treatment of trophic ulcers in patients with diabetes mellitus (literature review). Humans and their health. 2022; 1: 35-44. Russian (Терехов А.Г., Клюева Е.Г. Современное представление о способах лечения трофических язв у пациентов с сахарным диабетом (обзор литературы) //Человек и его здоровье. 2022. № 1. С. 35-44.) doi: 10.21626/vestnik/2022-1/05
Stepanova TV, Ivanov AN, Tereshkina NE, Popyhova EB, Lagutina DD. Markers of endothelial dysfunction: pathogenetic role and diagnostic significance. Klinicheskaya Laboratornaya Diagnostika. 2019; 64(1): 34-41. Russian (Степанова Т.В., Иванов А.Н., Терешкина Н.Е., Попыхова Э.Б., Лагутина Д.Д. Маркеры эндотелиальной дисфункции: патогенетическая роль и диагностическое значение (обзор литературы) //Клиническая лабораторная диагностика. 2019. Т. 64, № 1. С. 34-41)
Dedov II, Shestakova MV, Mayorov AY, Vikulova OK, Galstyan GR, Kuraeva TL, et al. Standards of specialized diabetes care. Diabetes mellitus. 2017; 20(1S): 1-121. Russian (Дедов И.И., Шестакова М.В., Майоров А.Ю., Викулова О.К., Галстян Г.Р., Кураева Т.Л. и др. Алгоритмы специализированной медицинской помощи больным сахарным диабетом //Сахарный диабет. 2017. № 1S. С. 1-121.) doi: 10.14341/DM20171S8
Mudrov V.A. Statistical analysis algorithms of quantitative features in biomedical researchusing the SPSS software package. Transbaikalian Medical Bulletin. 2020; 1: 151-163. Russian (Мудров В.А. Алгоритмы статистического анализа количественных признаков в биомедицинских исследованиях с помощью пакета программ SPSS //Забайкальский медицинский вестник. 2020. № 1. С. 151-163.) doi: 10.52485/19986173_2020_1_151
Amoli MM, Hasani-Ranjbar Sh, Roohipour N, Sayahpour FA, Amiri P, Zahedi P, et al. VEGF gene polymorphism association with diabetic foot ulcer. Diabetes Res Clin Pract. 2011; 93(2): 215-219. doi: 10.1016/j.diabres.2011.04.016
Erdogan M, Kulaksizoglu M, Tetik A, Solmaz S, Kucukaslan AS, Eroglu Z. The relationship of the endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VEGF) gene polymorphism in Turkish type 2 diabetic patients with and without diabetic foot ulcers. Foot (Edinb). 2018; 37: 5-10. doi: 10.1016/j.foot.2018.06.006
Li X, Lu Y, Wei P. Association between VEGF genetic variants and diabetic foot ulcer in Chinese Han population: a case–control study. Medicine. 2018; 20: 97. doi: 10.1097 /MD.0000000000010672
Rusanov AV, Chumachenko YaD, Dubovyk YI, Garbuzova VYu, Ataman AV. Analysis of the association between C936T VEGFA gene polymorphism and diabetic foot syndrome in the Ukrainian population. Research results in biomedicine. 2019; 5(2): 34-42. Russian (Русанов А.В., Чумаченко Я.Д., Дубовик Е.И., Гарбузова В.Ю., Атаман А.В. Анализ связи С936Т-полиморфного сайта гена VEGFA с развитием синдрома диабетической стопы в украинской популяции. //Научные результаты биомедицинских исследований. 2019. Т. 5, № 2. С. 34-42.) doi: 10.18413/2658-6533-2019-5-2-0-4
Ahmed ST, Ewadh MJ, Jeddoa ZMA. The association of vascular endothelial growth factor polymorphism (rs699947) with diabetic foot ulcer and oxidative status. Gene Reports. 2020; 19(1): 100606. doi: 10.1016/j.genrep.2020.100606
Ganapathy P, Sheshadri VDD, Sarkar R, Jones S, Gunasekaran K, Feysia TO, et al. Vascular Endothelial Growth Factor Single Nucleotide Polymorphism+ 405 G/C (rs2010963) is associated with Levels, Infection Severity, and Amputation among South Indian Diabetic Foot Ulcer Patients. Evid Based Complement Alternat Med. 2023; 2023: 2059426. doi: 10.1155/2023/2059426