FREQUENCY OF OCCURRENCE OF ANTIBODIES TO HLA ANTIGENS IN RECIPIENTS ON THE WAITING LIST FOR KIDNEY TRANSPLANTATION
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Abstract
Antibodies (a/t) to antigens (a/g) of human tissue compatibility HLA (human leucocyte antigens) are the main cause of kidney transplant rejection.
Antigens of the HLAI class system (loci A, B, C) are present on all nucleated cells of the body, HLA class II antigens (loci DR, DQ, DP) are expressed mainly on activated T-lymphocytes, B-lymphocytes, as well as cells of the phagocytic system. The cause of sensitization is previous transplantations, transfusions of donor blood components, pregnancy.
The ability to determine the specificity of antibodies to antigens of the HLA tissue compatibility system allows for a personal, virtual cross-match, which minimizes the risk of ultra-acute and accelerated transplant rejection.
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