SEX DIFFERENCES OF VLF100 AND VLF50 SPECTRUM OF HEART RATE VARIABILITY IN HEALTHY INDIVIDUALS OF YOUNG AGE AND OLDER SUBJECTS WITH VASCULAR PATHOLOGY IN TERMS OF SEVEN-TEST, HYPERVENTILATION AND ORTHOSTASIS
Main Article Content
Abstract
Subject. About minute rhythms of heart rate variability (HRV) (VLF100 and VLF50) and their role in sex differences of HRV and autonomic provision of the body.
Objective – to give a comparative evaluation of sex differences of the autonomic provision of the body in young adults of different constitutional and autonomic types and in the subjects of older age in vascular pathology in terms of functional loads based on the analysis of new indices of the oscillations with a period of 100 seconds (VLF100) and the oscillations with a period of 50 seconds (VLF50) in the spectrum of heart rate variability.
Methods. Physiological methods included a five-step registration of heart rate with functional tests of low intensity (seven-test, deep breathing and active orthostasis). Mathematical methods are the following: spectral analysis of HRV based on continuous wavelet transform and Hilbert-Huang transform, correlation analysis.
Main results. Sex differences were detected best in young people as under autonomic balance, as with the predominance of sympathetic or parasympathetic processes in terms of VLF100 and VLF50 in the combination with the oscillations of 10 seconds (LF) and the oscillations of high frequency (HF) and correlation analysis. Sex differences were significantly reduced in older individuals with tachycardia with a marked decrease of energy of wave processes. Unlike women functional loads increased the power of 10 sec. rhythms in men with vagal dominance. In the adaptive processes during orthostatic load sex differences were determined in individuals with initial optimal autonomic support.
Conclusion. The results of sex differences of the new VLF100 and VLF50 indicators and their interconnection with LF and HF were essential to the study of autonomic provision in the body, characterizing central mechanisms of regulation.Keywords
Author Biographies
Арнольд Наумович Флейшман,
Fleishman Arnold Naumovich
MD, professor, head of the laboratory of physiology of slow wave processes
Татьяна Валентиновна Кораблина,
associate professor, the chair of informatics and control systemsИгорь Германович Халиулин,
candidate of biological sciences, research fellowСтанислав Альфредович Петровский,
junior research fellow, the laboratory of physiology of slow wave processesАртем Андреевич Неретин,
an engineer, the laboratory of physiology of slow wave processesArticle Details
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
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References
Voss A, Schroeder R, Heitmann A, Peters A, Perz S. Short-term heart rate variability – influence of gender and age in healthy subjects. PloS one. 2015; 10 (3): e0118308
Heart rate variability. standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology the North American Society of Pacing Electrophysiology. Circulation. 1996; 95(5): 1043-1065
Taylor JA, Carr DL, Myers CW, Eckberg DL. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation. 1998; 98(6): 547-555
Akselrod S, Gordon D, Madwed JB, Snidman NC, Shannon DC, Cohen RJ. Hemodynamic regulation: investigation by spectral analysis. Am. J. Physiol. 1985; 249: H867-H875
Fleishman AN. Heart rate variability and slow oscillations hemodynamics. Nonlinear phenomena: a Teaching Atlas for clinicians. Novosibirsk: SO RAN Publishing House, 2009. 194 p. Russian (Флейшман А.Н. Вариабельность ритма сердца и медленные колебания гемодинамики. Нелинейные феномены: Учебный атлас для врачей. Новосибирск: Изд-во СО РАН, 2009. 194 с.)
Fleishman AN, Shumeiko NI, Karpenko SV, Sin AF, Dinges VR, Golik AS et al. Autonomic aspects of adaptation of rescuers to the insulating PPE In: Slow oscillatory processes in human body: theoretical and applied aspects of nonlinear dynamics in physiology and medicine: the materials of the All-Russian Symposium V with international participation and the School-Seminar III. Novokuznetsk, 2007. p. 164-174. Russian (Флейшман А.Н., Шумейко Н.И., Карпенко С.В., Син А.Ф., Дингес В.Р., Голик А.С. и др. Нейровегетативные аспекты адаптации горноспасателей к изолирующим средствам индивидуальной защиты //Медленные колебательные процессы в организме человека: теоретические и прикладные аспекты нелинейной динамики в физиологии и медицине: матер. V Всерос. симп. с междунар. участием и III Школы-семинара. Новокузнецк, 2007. С. 164-174)
Fleishman AN, Korablina TV, Doroshenko VA, Petrovsky SA. Very low frequency of heart rate variability: a new look at structure and properties. In: Slow oscillatory processes in the human body. Theoretical and applied aspects of nonlinear dynamics in physiology and medicine: the materials of the All-Russian Symposium VII and the School-Seminar V with international participation. Novokuznetsk, 2015. P. 12-23. Russian (Флейшман А.Н., Кораблина Т.В., Дорошенко В.А., Петровский С.А. Very low frequency вариабельности ритма сердца: новый взгляд на структуру и свойства //Медленные колебательные процессы в организме человека. Теоретические и прикладные аспекты нелинейной динамики в физиологии и медицине: матер. VII Всерос. симп. с междунар. участием и V Школы-семинара. Новокузнецк, 2015. С. 12-23)
Fleishman AN, Korablina TV, Petrovsky SA, Martynov ID. Complex structure and the nonlinear behavior of very low frequency of heart rate variability: models of analysis and practical application. News of higher educational institutions. Applied nonlinear dynamics. 2014; 22(1): 55-70. Russian (Флейшман А.Н., Кораблина Т.В., Петровский С.А., Мартынов И.Д. Сложная структура и нелинейное поведение very low frequency вариабельности ритма сердца: модели анализа и практические приложения //Известия высших учебных заведений. Прикладная нелинейная динамика. 2014. Т. 22, №. 1. С. 55-70)
Watanabe E, Kiyono K, Hayano J, Yamamoto Y et al. Multiscale entropy of the heart rate variability for the prediction of an ischemic stroke in patients with permanent atrial fibrillation. PloS one. 2015; 10 (9): e0137144
Smith FE, Bowers EJ, Langley P, Allen J, Murray A. Heart rate variability characteristics required for simulation of interval sequences. Computers in Cardiology. 2002; 29: 237-240
Fumiharu Togo, Ken Kiyono, Zbigniew R. Struzik, Yoshiharu Yamamoto. Unique very low-frequency heart rate variability during deep sleep in humans. IEEE Transactions on Biomedical Engineering. 2006; 53(1): 28-34
Kuklin SG, Mikhalevich IM, Rozhkova NYu, Dzizinskii AA, Titov YuM, Temnikov AA. New about oscillatory processes in heart rhythm (continuous wavelet analysis). Space and Time. 2013; (4): 216-223. Russian (Куклин С.Г., Михалевич И.М., Рожкова Н.Ю., Дзизинский А.А.,Титов Ю.М., Темников А.А. Новое о колебательных процессах в сердечном ритме (непрерывный вейвлет-анализ) //Пространство и время. 2013. № 4. C. 216-223)
Fleishman AN. Energy deficient state, autonomic regulation of physiological functions and heart rate variability. In: Slow oscillatory processes in the human body. Theoretical and applied aspects of nonlinear dynamics in physiology and medicine : the materials of the All-Russian Symposium IV and the School-Seminar II with international participation. Novokuznetsk, 2005. P. 10-19. Russian (Флейшман А.Н. Энергодефицитные состояния, нейровегетативная регуляция физиологических функций и вариабельность ритма сердца //Медленные колебательные процессы в организме человека. Теоретические и прикладные аспекты нелинейной динамики в физиологии и медицине: матер. IV Всерос. симп. с междунар. участием и II школы-семинара. Новокузнецк, 2005. С. 10-19)
Fleishman AN, Martynov ID, Petrovsky SA, Korablina TV. Orthostatic tachycardia: diagnostic and prognostic value of very low frequency of heart rate variability. Bulletin of the Siberian medicine. 2014; 13(4): 136-148. Russian (Флейшман А.Н., Мартынов И.Д., Петровский С.А., Кораблина Т.В. Ортостатическая тахикардия: диагностическое и прогностическое значение very low frequency вариабельности ритма сердца //Бюллетень сибирской медицины. 2014. Т. 13, № 4. С. 136-148)