Main Article Content
Abstract
Severe neonatal hypoxic-ischemic encephalopathy is one of the most important health and social problems due to the high morbidity and mortality in this group of children. The only method that can reduce the risk of adverse outcomes, a moderate total therapeutic hypothermia (TTG) is achieved by using a specialized cooling equipment (high-tech), or the use of simple means of cooling, such as ambient temperature and water packets (low-tech). The effectiveness of this technique has only provided it is an early start (within 6 hours of birth), duration of not less than 72 hours, subject to strict temperature range 33,0-34,0°C, as well as the full volume of resuscitation and intensive care of the newborn. If newborn requiring TTG born outside third-level hospital, it is necessary to start at the stage of the referral hospital, with subsequent transport as soon as possible at the cooling center. These guidelines describe how to identify patients in need of TTG, the sequence of TTG on stages of the referral hospital, transport and cooling center, as well as issues of intensive care and laboratory examination of this group of patients.
Keywords
Article Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Иванов, Д.О. Руководство по перинатологии /Иванов Д.О. – СПб.: Информ-Навигатор, 2015. – 1216 с.
Пальчик, А.В. Гипоксически-ишемическая энцефалопатия новорожденных /Пальчик А.В. – СПб.: Питер, 2000
Volpe, J.J. Neurology of newborn. 5th ed. /Volpe J.J. – Philadelphia: WB Saunders, 2008
Long-term clinical efficacy of mild hypothermia therapy in neonates with hypoxic-ischemic encephalopathy: a Meta analysis /Cao C.Q., Li Y.N., Yang X.M., Gong Y.G., Wang F., Li W.G. //Zhongguo Dang Dai Er Ke Za Zhi. – 2015. – V. 17(2). – P. 122-127
Cooling for newborns with hypoxic ischaemic encephalopathy /Jacobs S.E., Berg M., Hunt R., Tarnow-Mordi W.O., Inder T.E., Davis P.G. //Cochrane Database Syst. Rev. – 2013. – V. 31(1). – P. CD003311
Методика проведения лечебной гипотермии детям, родившимся в состоянии асфиксии /Антонов А.Г., Ионов О.В., Киртбая А.Р., Балашова Е.Н., Никитина И.В., Рындин А.Ю., Морошник Е.В., Дегтярев Д.Н. //Анестезиология и реаниматология. – 2014. – ¹ 6. – С. 76-77
Амплитудно-интегрированная электроэнцефалография и селективная церебральная гипотермия в неонатологической практике /Дегтярев Д.Н., Ионов О.В., Киртбая А.Р., Ушакова Л.В., Boone T., Амирханова Д.Ю., Кириллова Е.А., Никифоров Д.В. – М.: Локус Станди, 2013. – 60 с.
Протокол проведения лечебной гипотермии детям, родившимся в асфиксии /Ионов О.В., Балашова Е.Н., Киртбая А.Р., Антонов А.Г., Морошник Е.В., Дегтярев Д.Н. //Неонатология: новости, мнения, обучение. – 2014. – №2. – С. 81-83
Детская неврология: клинич. реком., вып. 3 /Гузеева В.И. и др. – М., 2015. – 336 с.
Иванов, Д.О. Нарушение теплового баланса у новорожденных детей. Приложение № 3, клинический протокол ведения новорожденных детей гестационного возраста 35 недель и более, перенесших тяжелую сочетанную и интранатальную асфиксию с использованием системной пассивной гипотермии для защиты мозга новорожденных с гипоксически-ишемической энцефалопатией /Иванов Д.О. – СПб.: Изд-во Н-Л, 2012
Специализированная реанимация новорожденного /Надишаускене Р.Й. и др. – Литва: Центр исследования кризисов, Университет наук здоровья Литвы, 2012. – 396 с.
Infant Cooling Evaluation Collaboration. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial /Jacobs S.E., Morley C.J., Inder T.E. et al. //Arch. Pediat. Adolesc. Med. – 2011. – V. 165(8). – P. 692-700
National Institute of Child Health and Human Development Neonatal Research Network. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy /Shankaran S., Laptook A.R., Ehrenkranz R.A., Tyson J.E., McDonald S.A., Donovan E.F. et al. //N. Engl. J. Med. – 2005. – V. 353(15). – P. 1574-1584
Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China /Zhou W.H., Cheng G.Q., Shao X.M., Liu X.Z., Shan R.B., Zhuang D.Y. et al. China Study Group. //J. Pediat. – 2010. – V. 157(3). – P. 367-372
Hypothermia and neonatal encephalopathy /Committee on Fetus and Newborn, Papile L.A., Baley J.E., Benitz W., Cummings J., Carlo W.A., Eichenwald E., Kumar P., Polin R.A., Tan R.C., Wang K.S. //Pediatrics. – 2014
Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomized trial /Gluckman P.D., Wyatt J.S., Azzopardi D., Ballard R., Edwards A.D., Ferriero D.M. et al. //Lancet. – 2005. – V. 365(9460). – P. 663-670
Pharmacokinetics and pharmacodynamics of medication in asphyxiated newborns during controlled hypothermia: The PharmaCool multicenter study /de Haan T.R., Bijleveld Y.A., van der Lee J.H., Groenendaal F., van den Broek M.P., Rademaker C.M. et al. //BMC Pediatr. – 2012. – V. 22. – P. 12-45