PREDICTORS OF CONGENITAL INFECTION IN FULL-TERM NEWBORNS: A RETROSPECTIVE STUDY OF RISK FACTORS AND CLINICAL CHARACTERISTICS
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Abstract
Intrauterine or congenital infections (CI) are the actual problems in obstetrics and perinatology and a significant part among the causes of neonatal mortality (30%). Traditional factors are not always acceptable for identifying a high-risk group of CI, especially in relation to full-term newborns.
The aim of the research – шmproving the effectiveness of diagnosis of CI in the antenatal period by updating risk factors.
Materials and methods. A retrospective cohort study «case-control» was conducted (n = 191) and the risk factors of CI were studied, including the features of the somatic and obstetric-gynecological anamnesis, the course of pregnancy, childbirth and the postpartum period. Patients were divided into 2 groups depending on the perinatal outcome: group I (main group) – patients whose children had CI (n = 141), group II (control group) – patients whose children had no infectious pathology (n = 50). Statistical data processing was carried out using parametric and nonparametric methods of applied mathematical statistics. The differences between the groups were considered significant at p < 0.05.
Results. The study made it possible to identify the most significant risk factors for CI in full-term newborns, including colonization of the urogenital tract of pregnant women with Candida spp. before labor, some features of managing patients with vaginal infections during gestation, the maternal general infectious load and the male sex of the fetus.
Conclusion. Improvement the examination algorithm for pregnant women from risk groups will increase the effectiveness of antenatal diagnosis of CI.
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