OVARIAN CANCER: INCIDENCE DYNAMICS IN NOVOKUZNETSK RESIDENTS FOR THE PERIOD 2008-2020
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Abstract
The etiology and pathogenesis of ovarian cancer have not been fully studied. The disease proceeds aggressively, is characterized by late diagnosis, high mortality rate and significant prevalence rate in economically developed countries. Novokuznetsk is a major industrial center of Kuzbass, and one of the most environmentally unfriendly regions in the Russian Federation, with a high cancer morbidity and mortality of the population, which is the reason for the analysis.
The purpose of the study. To study the dynamics of ovarian cancer rate in the residents of Novokuznetsk from 2008 to 2020 and to conduct a comparative analysis with the average incidence rates in Russia and a number of other countries.
Research methods. Statistical reports of the regional clinical oncological dispensary (Novokuznetsk branch) for 2008-2020 were used for the analysis. The licensed statistical package IBM SPSS Statistics-19 was used for the analysis. The following statistical methods were used: calculation of median values of indicators, upper and lower quartiles; Kendall tau rank correlation coefficient method (Ʈ), Mann–Whitney U test (U).
Results. During the study period, there was a tendency to decrease the absolute incidence of ovarian cancer along with a significant increase in five-year survival rate. High mortality was recorded in the 1st year of observation, along with predominantly late diagnosis of the disease (III and IV stages). The risk zone included women of postmenopausal age – 65-69 years.
Conclusion. High mortality rates of ovarian cancer patients in the 1st year of observation are due to late detection, which requires the legalization of screening programs with the inclusion of biochemical markers of tumors of various histotypes in the algorithm and coverage of women, except for unemployed, but at the same time under high cancer risk (65-69 years).
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