MAIN HEALTH INDICATORS OF INFANTS FROM INDUCED SINGLE PREGNANCY
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Abstract
The aim of the research - to study the influence of the reproductive health of parents with a history of infertility, the somatic health of the mother and the course of pregnancy on the health of children born with singleton IVF pregnancy.
Material and methods. А retrospective case-control study was carried out. The main group consisted of all newborns from singleton ART born in the Avicenna medical center (Novosibirsk) in the period from 2007 to 2017. (n = 409). The control group consisted of 210 newborns from singleton spontaneous pregnancy, without a history of infertility of parents, whose mothers' obstetric and gynecological history was not burdened (the parity of pregnancies is equal to the parity of childbirth), born in the same period.
Results. Children born of ART, despite the multiple factors associated with the somatic health of the mother and the complicated course of pregnancy, have similar characteristics in the main groups of pathological conditions / nosologies with children born in couples without a history of infertility.
Conclusion. Comprehensive, interdisciplinary medical support for couples at all stages of infertility treatment, with the timely detection and correction of emerging complications of pregnancy, allows to neutralize the negative factors associated with the reproductive and somatic health of parents, and lead to the birth of children with ART, comparable in the main indicators of health to children, born from a spontaneous pregnancy.
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Author Biographies
Мария Константиновна Соболева, Novosibirsk State Medical University
Soboleva Maria Konstantinovna
MD, PhD, professor, head of hospital pediatrics department.
She is a consultant and curator of the Department of Intensive Care, Nephrology and Respiratory infections since 1991, Cardiorheumatology since 1997.
She is also the main non-staff specialist of the Main Department of Health of the Mayor of Novosibirsk in pediatric cardiology/rheumatology and hematology, a member of the Editorial Board of the “Pediatrics” journal.
Under her supervision there were defended 8 Candidate and one Doctoral dissertations. She is an author of more than 400 scientific publications, chapters in monographs and studying manuals of the Federal level, scientific articles and reviews.
She is a member of the New York Academy of Sciences, a member of the Scientific Committees of the Ministry of Health of the Russian Federation in pediatric cardiology, orphan diseases and of working group of experts in pediatric nephrology of the Scientific Center of Children's Health, Moscow.
She was awarded honorary diplomas of the Ministry of Health and Social Development of the Russian Federation, “Outstanding Health Care Worker”, diplomas of the Head of Administration of Novosibirsk and the Governor of the Novosibirsk region.Дарья Александровна Киншт, Novosibirsk State Medical University
assistant, department of pediatrics and neonatologyReferences
Inhorn MC, Patrizio P. Infertility Around the Globe: New Thinking on Gender, Reproductive Technologies and Global Movements in the 21st Century. Hum Reprod Update. 2015; 21(4): 411-426
Crawford GE, Ledger WL. In Vitro fertilisation/intracytoplasmic Sperm Injection Beyond 2020. BJOG. 2019; 126(2): 237-243
Korsak VS. VRT register. 2017 Annual Report. [Electronic document]. – Access mode: http://www.rahr.ru/d_registr_otchet/RegistrART2017.pdf (Корсак В.С. Регистр ВРТ. Отчет за 2017 год. Электронный документ)
Baranov AA, Namazova-Baranova LS, Belyaev IA, Bombardirova EP, Smirnov IE. Medical and social problems of assisted reproductive technologies from the perspective of pediatrics. Bulletin of the Russian Academy of Medical Sciences. 2015; 70(3): 307-314. Russian (Баранов А.А., Намазова-Баранова Л.С., Беляев И.А., Бомбардирова Е.П., Смирнов И.Е. Медико-социальные проблемы вспомогательных репродуктивных технологий с позиции педиатрии //Вестник российской академии медицинских наук. 2015. Т. 70, № 3. С. 307-314)
Bergh C, Wennerholm UB. Long-term Health of Children Conceived After Assisted Reproductive Technology. Ups J Med Sci. 2020; 125(2): 152-157
Sullivan-Pyke CS, Senapati S, Mainigi MA, Barnhart KT. In Vitro fertilization and adverse obstetric and perinatal outcomes. Semin Perinatol. 2017; 41(6): 345-353
Murzakhanova AF, Oslopov VN, Khazova EV. The health state of children born after in vitro fertilization: probable risks and possible complications. Practical medicine. 2020; 18(3): 43-50. Russian (Мурзаханова А.Ф., Ослопов В.Н., Хазова Е.В. Состояние здоровья детей, рожденных после экстракорпорального оплодотворения: вероятные риски и возможные осложнения //Практическая медицина. 2020. Т. 18, № 3. С. 43-50)
Sansone A, Di Dato C, Angelis C, Menafra D, Pozza C, Pivonello R et al. Smoke, Alcohol and Drug Addiction and Male Fertility. Reprod Biol Endocrinol. 2018; 16(1): doi: 10.1186/s12958-018-0320-7
Hansen M, Bower C. The impact of assisted reproductive technologies on intra-uterine growth and birth defects in singletons. Semin. Fetal. Neonatal. Med. 2014; 19(4): 228-233
Nikitin AI. Once again about the health of children after IVF (literature review). Reproduction problems. 2019; 25(3): 28-33. Russian (Никитин А.И. Еще раз о здоровье детей после ЭКО (обзор литературы). Проблемы репродукции. 2019. Т. 25. № 3. С. 28-33)
Keshishyan ES, Tsaregorodtsev AD, Ziborova MI. Health status and development of children born after in vitro fertilization. Russian Bulletin of Perinatology and Pediatrics. 2014; 59(5): 15-25. Russian (Кешишян Е.С., Царегородцев А.Д., Зиборова М.И. Состояние здоровья и развитие детей, рожденных после экстракорпорального оплодотворения //Российский вестник перинатологии и педиатрии. 2014. Т. 59, № 5. С. 15-25)
Qin JB, Sheng XQ, Wang H, Chen GC, Yang J, Yu H, Yang TB. Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization/intracytoplasmic sperm injection among multiple births: a systematic review and meta-analysis based on cohort studies. Arch Gynecol Obstet. 2017; 295(3): 577-597
Berntsen S, Söderström-Anttila V, Wennerholm UB, Laivuori H, Loft A, Oldereid NB et al. The Health of Children Conceived by ART: The Chicken or the Egg? Hum Reprod Update. 2019; 25(2): 137-158