THRESHOLD VALUES OF ANTIBODIES TO ESTROGEN, PROGESTERON AND BENZO[A]PYRENE AS A RISK FACTOR OF THE DEVELOPMENT OF EXTERNAL GENITAL ENDOMETRIOSIS
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Abstract
The purpose of the study – to determine the level of antibodies (AT) of Ig classes A and G to estradiol (E2), progesterone (P) and benzo[a]pyrene (Bp) in patients with endometriosis of varying severity and establish their threshold values as a risk factor for the development of external genital endometriosis.
Materials and methods. A retrospective case – control study was conducted. The study included 200 women. Group I – women with external genital endometriosis (n = 100), Group II – patients with tuboperitoneal infertility (n = 100). All patients underwent an immunological study of blood serum, determined levels of steroid hormones (P, E2), antibodies to them and Bp. To identify the threshold levels of AT, a ROC analysis was performed.
Results. In women with external genital endometriosis, significantly higher levels of AT IgA and IgG to E2, P and benzo[a]pyrene were detected, compared with women of group II. The threshold levels of IgA-Bp, IgA-E2 and IgA-P are > 5 UE, IgG-Bp, IgG-E2 > 9 UE and IgG-P > 8 UE. The level of IgG-P in patients with severe forms of endometriosis is statistically significantly higher than in small forms of the disease. In severe forms, there is a tendency to increase other classes of antibodies.
Conclusion. Patients with external genital endometriosis are characterized by higher levels of IgA and IgG to Bp, E2, P. Their threshold values, which are risk factors for developing the disease, have been established.
Keywords
Author Biographies
Наталья Владимировна Артымук,
Artymuk Natalia Vladimirovna
MD, PhD, professor, deputy editor of the journal Mother and Baby in Kuzbass.
She is the Head of the Department of Obstetrics and Gynaecology №2, the Deputy Editor-in-Chief. She is also the President of the Kemerovo regional public organization “Association of obstetricians and gynecologists”, the chief obstetrician-gynecologist of the Siberian Federal district; the member of the Board of the Russian Society of Obstetricians and Gynaecologists, the member of the European Society of Contraception and Reproductive Health, the European Society of Gynaecological Oncology and the International Society of Gynecological Endocrinology.
She has graduated from Kemerovo State Medical institute with honors. She studied in clinical residency in obstetrics and gynecology at School of Arenberg (Salzburg, Austria) and School of Bloomberg (Johns Hopkins University, Baltimore, USA). One is a specialist in ultrasound diagnostics in obstetrics and gynecology, endocrinology and endoscopic surgery. In 1996 in Barnaul she defended her PhD thesis and her doctoral thesis in 2003 in Moscow.
Her priorities are: endocrine gynecology, infertility, cervix uteri pathology, menopausal disorders, disorder of menstrual function, endoscopic and abdominal gynecological surgery.
She deals with reproductive health problems, non-surgical and surgical treatment of benign neoplasms of genital organs. She is an author of more than 450 scientific works, including 3 monographs and study manuals for doctors. She has her highest medical qualification category in “Obstetrics and gynecology”.
Виталий Олегович Червов,
postgraduate student, the department of obstetrics and gynecology N 2Лариса Николаевна Данилова,
head of the department gynecologicalЕлена Геннадьевна Поленок,
candidate of pharmacy sciences, chief of immunochemistry laboratoryArticle Details
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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