ANTIBODIESTOBENZO [A] PYREN, ESTRADIOL AND PROGESTERON IN WOMEN WITH EXTERNAL GENITAL ENDOMETRIOSIS
Main Article Content
Abstract
Objective – to study the social and household characteristics and specific immune responses to hormone-like xenobiotics and sex steroids in women with endometriosis.
Materials and methods. A retrospective case-control study was conducted. The study included 200 women. Group I – women with a verified diagnosis of IEG (n = 100), Group II – women with tubal genesis infertility (n = 100). Using non-competitive enzyme immunoassay, all women in the studied groups studied serum antibodies (AT) of the IgA and IgG class specific for benzo[a]pyrene (BP), estradiol (ES) and progesterone (PG). The threshold values of antibodies associated with an increased risk of endometriosis were identified.
The results. Women with endometriosis are more often subject to increased exposure to EDS, due to active and passive smoking. In patients with endometriosis, the levels of IgA and IgG antibodies to steroid hormones and benzo[a]pyrene are statistically significantly higher.
Conclusion. The effects of EDS can be considered a risk factor for endometriosis.
Keywords
Author Biographies
Виталий Олегович Червов,
postgraduate student, the department of obstetrics and gynecology N 2Наталья Владимировна Артымук,
Artymuk Natalia Vladimirovna
MD, PhD, professor, deputy editor of the journal Mother and Baby in Kuzbass.
She is the Head of the Department of Obstetrics and Gynaecology №2, the Deputy Editor-in-Chief. She is also the President of the Kemerovo regional public organization “Association of obstetricians and gynecologists”, the chief obstetrician-gynecologist of the Siberian Federal district; the member of the Board of the Russian Society of Obstetricians and Gynaecologists, the member of the European Society of Contraception and Reproductive Health, the European Society of Gynaecological Oncology and the International Society of Gynecological Endocrinology.
She has graduated from Kemerovo State Medical institute with honors. She studied in clinical residency in obstetrics and gynecology at School of Arenberg (Salzburg, Austria) and School of Bloomberg (Johns Hopkins University, Baltimore, USA). One is a specialist in ultrasound diagnostics in obstetrics and gynecology, endocrinology and endoscopic surgery. In 1996 in Barnaul she defended her PhD thesis and her doctoral thesis in 2003 in Moscow.
Her priorities are: endocrine gynecology, infertility, cervix uteri pathology, menopausal disorders, disorder of menstrual function, endoscopic and abdominal gynecological surgery.
She deals with reproductive health problems, non-surgical and surgical treatment of benign neoplasms of genital organs. She is an author of more than 450 scientific works, including 3 monographs and study manuals for doctors. She has her highest medical qualification category in “Obstetrics and gynecology”.
Лариса Николаевна Данилова,
head of the department gynecologicalЕлена Геннадьевна Поленок,
candidate of pharmacy sciences, chief of immunochemistry laboratoryArticle Details
Information about financing and conflict of interests
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
How to Cite
References
Smarr MM, Kannan К, Buck Louis GM. Endocrine disrupting chemicals and endometriosis. Fertility and Sterility. 2016; 106(4): 959-966. DOI: https://doi.org/10.1016/j.fertnstert.2016.06.034
Senapati S. Barnhart K. Managing Endometriosis Associated Infertility. Clin Obstet Gynecol. 2011; 54(4): 720-726. DOI: 10.1097/ GRF. 0b013e3182353e 06PMCID:PMC3383664
Fauconnier A, Chapron C. Endometriosis and pelvic pain: epidemiological data on the relationship and consequences. Update Hum Reprod. 2005; 11: 595-606
Giulivo M, Lopez de Alda M, Capri E, Barcelo D. Human exposure to endocrine disrupting compounds: Their role in reproductive systems, metabolic syndrome and breast cancer. A review. Environ. Res. 2016; 151: 251-264
Bruner-Tran KL, Mokshagundam S, Herington JL, Ding T, Osteen KG. Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets. Current Women’s Health Reviews. 2018; 14(2): 173-188. DOI: 10.2174/1573404813666170921162041
Greiner M, Pfeiffer D, Smith RD. Priciples and practical application of the receiver operating characteristic analysis for diagnostic test. Prev. Vet. Med. 2000; (45): 23-41
Chervov VO, Artymuk NV, Danilova LN. Hormon-like xenobiotics and gynecological problem. Literature review. Mother and Child in Kuzbass. 2018; (2): 20-26. Russian. (Червов В.О., Артымук Н.В., Данилова Л.Н. Гормоноподобные ксенобиотики и гинекологические проблемы //Мать и Дитя в Кузбассе. 2018. № 2. С. 20-26)
Rekhadevi P, Diggs D, Huderson A, Harris K, Archibong A, Ramesh A. Metabolism of the environmental toxicant benzo(a)pyrene by subcellular fractions of human ovary. Human & Experimental Toxicology. 2014; 33(2): 196-202. DOI:10.1177/0960327113489050
Ewa B, Danuta M-S. Polycyclic aromatic hydrocarbons and PAH-related DNA adducts. Journal of Applied Genetics. 2017; 58(3): 321-330
Report on the state and environment protection of the Kemerovo region in 2017. Department of natural resources and ecology of the Kemerovo area [Electronic resource]. Access mode: http://kuzbasseco.ru/wp-content/uploads/2018/09/doklad_20172.pdf. Russian (Доклад о состоянии и охране окружающей среды Кемеровской области в 2017 году. Департамент природных ресурсов и экологии Кемеровской области [Электронный ресурс]. Режим доступа: http://kuzbasseco.ru/wp-content/uploads/2018/09/doklad_20172.pdf)
On the approval of hygienic standards of GN 2.1.6.3492-17 «Maximum allowable concentrations of pollutants in the atmospheric air of urban and rural settlements»: Resolution of the Chief State Sanitary Doctor of the Russian Federation of February 13, 2018 N 25 [Electronic resource]. Access mode: http://rospotrebnadzor.ru/upload/iblock/00b/gn-2.2.5.3532_18.pdf. Russian (Об утверждении гигиенических нормативов ГН 2.1.6.3492-17 «Предельно допустимые концентрации (ПДК) загрязняющих веществ в атмосферном воздухе городских и сельских поселений»: постановление Главного государственного санитарного врача Российской Федерации от 13 февраля 2018 года N 25 [Электронный ресурс]. Режим доступа: http://rospotrebnadzor.ru/upload/iblock/00b/gn-2.2.5.3532_18.pdf)
Bravi F, Parazzini F, Cipriani S et al. Tobacco smoking and risk of endometriosis: a systematic review and meta-analysis. BMJ Open. 2014; 4(12): e006325. DOI:10.1136/bmjopen-2014-006325
Goncalves RB, Coletta RD, Silverio KG et al. Impact of smoking on inflammation: overview of molecular mechanisms. Inflamm. Res. 2011; 60: 409-424. DOI:10.1007/s00011-011-0308-7
Yasui T, Hayashi K, Nagai K et al. Risk Profiles for Endometriosis in Japanese Women: Results From a Repeated Survey of Self-Reports. Journal of Epidemiology. 2015; 25(3): 194-203. DOI:10.2188/jea.JE20140124
Chapron C, Souza C, de Ziegler D, Lafay-Pillet MC, Ngô C, Bijaoui G et al. Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected women. Fertil Steril. 2010; 94: 2353-2355. DOI:10.1016/j.fertnstert.2010.04.020
Parasar P, Ozcan P, Terry KL. Endometriosis: Epidemiology, Diagnosis and Clinical Management. Current obstetrics and gynecology reports. 2017; 6(1): 34-41. DOI:10.1007/s13669-017-0187-1