JUVENILE IDIOPATHIC ARTHRITIS INDIGENOUS PEOPLES OF THE NORTH REPUBLIC OF SAKHA (YAKUTIA)

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2026-05-23

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Tatyana Egorovna Burtseva
North-Eastern Federal University named after M.K. Ammosov, 677000, Yakutsk, Belinskogo st., 58
Sargylana Gavrilevna Boeskorova
Republican Hospital N 1 – National Center of Medicine named after M.E. Nikolaev, 677000, Yakutsk, Sergelyakhskoye Highway, 4
Marina Viktorovna Afonskaya
Republican Hospital N 1 – National Center of Medicine named after M.E. Nikolaev, 677000, Yakutsk, Sergelyakhskoe highway, 4
Vera Mayichna Argunova
Republican Hospital N 1 – National Center of Medicine named after M.E. Nikolaev, 677000, Yakutsk, Sergelyakhskoe Highway, 4
Polina Andreevna Sleptsova
Yakutsk Science Center for Complex Medical Problems, 677000, Yakutsk, Yaroslavskogo str. 6/3
Sardana Anatolievna Evseeva
Yakutsk Science Center for Complex Medical Problems, 677000, Yakutsk, Yaroslavskogo str. 6/3
Vyacheslav Grigorevich Chasnyk
St. Petersburg State Pediatric Medical University, 194100, St. Petersburg, Litovskaya str. 2
Mikhail Mikhailovich Kostik
St. Petersburg State Pediatric Medical University, 194100, St. Petersburg, Litovskaya str. 2

Abstract

There is no data in the available literature on the description of juvenile idiopathic arthritis in the indigenous peoples of the North of Yakutia.
Objective: to describe the clinical characteristics, therapy, and outcomes of juvenile idiopathic arthritis (JIA) in children of indigenous peoples of the North (IPN) living in the Republic of Sakha (Yakutia).
Materials and methods: The study included data from 8 children of IPN with a diagnosis of JIA who were examined and treated in the cardiorheumatology department of the Pediatric Center of the Republican Hospital N 1 – the National Center of Medicine named after M.E. Nikolaev in 2016-2023. The methods of descriptive statistics are used in the work.
Results and discussion. Enthesitis-associated arthritis (EAA) dominates in the structure of the incidence of JIA in children with IPN (62,5%). A high frequency of HLA-B27 carriers (62,5%) was revealed. The onset of the disease is relatively late (the average age is 9,6 years). The joints of the lower extremities are mainly affected, and there is a high incidence of sacroiliitis. The severe course of the disease is characterized by low efficacy or poor tolerance of methotrexate, which required the appointment of genetically engineered biological drugs (GEBD) in 87,5% of cases.
Conclusion. In children of INP living in the Arctic and northern regions of the Republic of Sakha (Yakutia), JIA is characterized by pronounced clinical and genetic specificity: the predominance of HLA-B27-associated forms (EAA), late onset, frequent development of sacroiliitis and severe course of articular syndrome. The revealed resistance to methotrexate therapy and the high efficacy of TNF-α inhibitors justify the expediency of early administration of GEBD to achieve stable remission and prevent disability.

Keywords

juvenile idiopathic arthritis, enthesitis-associated arthritis, HLA-B27, etanercept, Yakutia

Author Biographies

Tatyana Egorovna Burtseva,

doctor of medical sciences, professor, professor of the department of pediatrics and pediatric surgery; leading researcher, head of the laboratory for monitoring the state of children's health and medical for environmental research

Sargylana Gavrilevna Boeskorova,

rheumatologist; postgraduate student at the department of pediatrics and pediatric surgery

Marina Viktorovna Afonskaya,

head of the cardiorheumatology department of the pediatric center

Vera Mayichna Argunova,

cardiorheumatologist

Polina Andreevna Sleptsova,

candidate of medical sciences, deputy director for pediatrics

Sardana Anatolievna Evseeva,

candidate of medical sciences, senior researcher

Vyacheslav Grigorevich Chasnyk,

doctor of medical sciences, head of the department of hospital pediatrics

Mikhail Mikhailovich Kostik,

doctor of medical sciences, professor, professor of the department of hospital pediatrics

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
© Tatyana Egorovna Burtseva, Sargylana Gavrilevna Boeskorova, Marina Viktorovna Afonskaya, Vera Mayichna Argunova, Polina Andreevna Sleptsova, Sardana Anatolievna Evseeva, Vyacheslav Grigorevich Chasnyk, Mikhail Mikhailovich Kostik, 2026


Creative Commons License  This work is licensed under a Creative Commons Attribution 4.0 License.

How to Cite

Burtseva, T. E., Boeskorova, S. G., Afonskaya, M. V., Argunova, V. M., Sleptsova, P. A., Evseeva, S. A., Chasnyk, V. G., & Kostik, M. M. (2026). JUVENILE IDIOPATHIC ARTHRITIS INDIGENOUS PEOPLES OF THE NORTH REPUBLIC OF SAKHA (YAKUTIA). Mother and Baby in Kuzbass, 2, 81-87. https://www.mednauki.ru/index.php/MD/article/view/1424

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