RISK OF FORMATION OF OBESITY, ARTERIAL HYPERTENSION AND METABOLIC SYNDROME AT YOUNG AGE DEPENDING ON THE BIRTH WEIGHT
Main Article Content
Abstract
The article presents the results of research based on the probative medicine methods estimating risk of excess adipopexis formation, arterial hypertension and metabolic syndrome at 374 people aged 17-29 depending on their birth weight (31 had birth weight under2500 g, 27 – over4000 gand 316 – 3000-3800 g). Formation of basic clinical insulin resistance markers (combination of excess adipopexis and arterial hypertension) at young age has associative relation both with low and high birth weight. Relative risk of metabolic syndrome in the presence of excess adipopexis is statistically much higher (more than 2 times) at newborns with low birth weight.
Downloads
Article Details
Issue
Section
References
Obesity: etiology, pathogenesis, clinical aspects. Ed. II Dedov, GA Melnichenko. M.: MIA, 2006. 452 p. Russian (Ожирение: этиология, патогенез, клинические аспекты /под ред. И.И. Дедова, Г.А. Мельниченко. М.: МИА, 2006. 452 с.)
Halldorsson ThI, Gunnarsdottir I, Birgisdottir BE et al. Childhood growth and adult hypertension in a population of high birth weight. Hypertension. 2011; (58): 8-15
Cheung YB, Low L, Osmond C et al. Fetal growth and early postnatal growth are related to blood pressure in adults. Hypertension. 2000; (36): 795-805
Ong K, Ahmed M, Emmett P et al. Association between postnatal catch-up growth and obesity in childhood: prospective cohort studies. BMJ; 2000. (320): 967-971
Eisenmann, J. C. Assessment of obese children and adolescents: a survey of pediatric obesity-management programs / J. C. Eisenmann // Pediatrics. – 2011. – Vol. 128. – P. 51-58
Eriksson JG, Forsen T, Tumilehto J. Early growth and coronary heart disease in later life: longitudinal study. BMJ. 2001; (322): 949-953
Kapoor A, Leen J, Matthews SG. Molecular regulation of the hypothalamic-pituitary-adrenal axis in adult male guinea pigs after prenatal stress at different stages of gestation. J. Physiol. 2008; 586(17): 4317-4326
The NS, Adair LS, Gordon-Larsen P. A Study of the birth weight–obesity relation using a Longitudinal Cohort and Sibling and Twin Pairs. Am. J. Epidemiol. 2010; (172): 549-557
Longas AF, Labarta JI, Mayayo E. Children born small for gestational age: multidisciplinary approach. Pediatr. Endocrinol. Rev. 2009; 6(3): 324-325
Nobili V, Alisi A, Panera N. Low birth and catch-up-growth associated with metabolic syndrome: a ten year systematic review. Aqostoni Pediatr. Endocrinol. Rev. 2008; 6(2): 241-247
Bokova TA. Risk factors for the formation of the metabolic syndrome in children. Pediatric practice. 2016; (2): 5-8. Russian (Бокова Т.А. Факторы риска формирования метаболического синдрома у детей //Практика педиатра. 2016. № 2. С. 5-8.)
Randhawa RS. The insulin-like factor system and fetal growth restriction. Pediatr. Endocrinol. Rev. 2008; 6(2): 235-240
Nagaeva EV. Intrauterine growth retardation. Pediatrics. 2009; 88(5): 140-146. Russian (Нагаева Е.В. Внутриутробная задержка роста //Педиатрия. 2009. Т. 88, № 5. С. 140-146.)
Singhal A, Fewtrell M, Cole TJ, Lucas A. Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet. 2003; 361(9376): 1089-1097
Gluckman PD, Hanson MA, Low FM. The role of developmental plasticity and epigenetics in human health. Birth Defects Research Part C: Embryo Today: Reviews. 2011; 93(1): 12-18