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Никита Андреевич Шабалдин
Сергей Иванович Головкин
Андрей Владимирович Шабалдин

Abstract

The study of disorders of systemic immunity and immune regulation in idiopathic transient synovitis of the hip joint (ITSHJ) and disease Legg-Calve-Perthes (DP) in children of early and school age. Studied 37 children with ITSHJ and 11 children with DP in the age interval of 3-12 years. The control group consisted of 29 healthy children. Investigated cytokine levels in the peripheral blood and the level of antibodies to conditionally pathogenic microflora. It is shown that ITSHJ and DP different in the immunopathogenesis of the disease. ITSHJ associated with allergic (atopic and immune) immune response to the antigens of pathogenic microorganisms and the herpes viruses and the development of infectious and allergic inflammation. DP associated with aseptic inflammation, developing on the background of high activity of IL-1Ra, TNF-a and induction of the rheumatoid factor. Pathogenetically justified in this pathology will be the appointment of drugs blocks the activity of TNF-a.

Keywords

the immune status, the transient synovitis of the hip joint, the Legg-Calve-Perthes disease, children

Author Biographies

Никита Андреевич Шабалдин,
assistant, chair of pediatric surgical diseases
Сергей Иванович Головкин,
doctor of medical sciences, professor, chair of pediatric surgical diseases
Андрей Владимирович Шабалдин,


Shabaldin Andrej Vladimirovich
MD, PhD, a leading researcher of the Laboratory of Cell Technologies.

He is a Professor of the Department of Otolaryngology and Clinical Immunology at Kemerovo State Medical University, the Principal Scientific Researcher of Research Institute for Complex Issues of Cardiovascular Diseases, the Principal Scientific Researcher of Kemerovo branch of the Institute of Computational Technologies of SB RAS.

In 1992 he graduated from Kemerovo State Medical Institute. After that he completed clinical residency and postgraduate studies at the Department of Children's Diseases at Kemerovo State Medical Institute. In 1997 he defended his dissertation “Genetic and Phenotypic Features of Immune Development in Children of Early Age Who Live in Kemerovo”.

From 1993 till present he still works at the Russian Academy of Sciences. He has risen from Junior Research Associate to Principal Scientific Researcher.

In 2005 he defended his Doctoral dissertation “Immunogenetic Aspects of Early Ontogenesis”.
Since 2009 till present he still works as a Professor at the Department of Otorhinolaryngology and Clinical Immunology at Kemerovo State Medical University.

His research directions are: immunoreproduction, immunity in sickly children and chronic children.
He has taught 4 Candidates of Medical Sciences. He also has 187 publications.

The total number of quotations according to the RSCI is 285, a personal h–index is 6.

The Administration of the Kemerovo region has awarded A. V. Shabaldin the medal “For Service to Kuzbass” and “For Worthy Child-Rearing”. In 2000 he was awarded the honorary diploma of Russian Academy of Sciences “For Longstanding Conscientious Labor the Russian Academy of Sciences”.

Article Details

Information about financing and conflict of interests

The study had no sponsorship.
The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.

How to Cite

Шабалдин, Н. А., Головкин, С. И., & Шабалдин, А. В. (2017). CLINICAL AND IMMUNOLOGICAL FEATURES OF TRANSIENT SYNOVITIS OF THE HIP JOINT AND DISEASE LEGG-CALVE-PERTHES IN CHILDREN OF EARLY AND SCHOOL AGE. Mother and Baby in Kuzbass, 17(1), 21-26. https://www.mednauki.ru/index.php/MD/article/view/115

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