MEDICAL AND SOCIAL CHARACTERISTICS OF MODERN INFERTILE WOMEN ACCORDING TO THE REGISTRY OF INFERTILITY COUPLES IN THE TRANSBAIKAL REGION
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Abstract
Aim – to identify medical and social factors of infertility in women living in the Trans-Baikal Territory.
Materials and methods. Retrospective comparative study. An analysis of the medical and social characteristics of patients with infertility was carried out according to the data of an electronic questionnaire, which has been developed based on materials from the World Health Organization [WHO-RHR-HRP-19.3]. 1st group included 103 women living in city; 2nd group – 85 women living in the village.
Results. The age of infertile patients living in the city was older than that of rural women: 36.0 (31.3; 39.0) vs 33.5 (29.8; 37.0) years (U = 3345.0, p = 0.032); menstrual cycle parameters differ only in the age of menarche, which was younger in city women: 13.0 (12.0; 14.0) vs 14.0 (13.0; 14.0) years (p = 0.041). Operations for tubal pregnancy were more often performed laparoscopically in the group of city women: 84.6 % vs 40.0 % (p = 0.044). No differences were found in frequency of such factors as regular taking medications, drinking alcohol, living near a source of toxic substances (landfill, mine, etc.). The proportion of smoking women was higher among rural residents: 19.4 % vs 34.1 % (p = 0.022). An equal number of comparison groups patients were previously examined for infertility, measured basal temperature, performed an ovulation test. But ultrasound monitoring of ovulation was performed more often in city residents: 32.0 % vs 14.1 % (p = 0.004).
Conclusion. Infertile patients are characterized by a long period (6 years) of examination and conservative treatment of infertility, have a complex of external negative factors (systematic medication, alcohol, tobacco smoking, exposure to toxic substances). Compliance with time parameters and volumes during examination and conservative treatment of infertility, elimination of adverse external influences can improve the result of treatment.
Keywords
Author Biographies
Татьяна Евгеньевна Белокриницкая,
Belokrinitskaya Tatiana Evgenievna
MD, PhD, professor, Chief of the chair of obstetrics and gynecology of pediatric faculty.
She graduated from Chita State Medical Academy, was a participant of 4th International Congress on thrombosis and hemostasis (Florence, Italy, 1997) and the 3rd Congress of the European Association of Gynecology and Obstetrics (Jerusalem, Israel, 1998).
She is also an author of 4 inventions, 500 scientific works published by Russian and foreign press, 38 study manuals for medical students, teachers and doctors. She is the editor of the annual collection of theoretical and practical works in “Topical Issues of Obstetrics, Gynecology and Perinatology”.
Наталия Ивановна Фролова,
doctor of medical sciences, docent, department of obstetrics and gynecology of the faculty pediatrics and faculty continuing professional educationДмитрий Владимирович Малько,
clinical resident, department of obstetrics and gynecology of the faculty pediatrics and faculty continuing professional educationArticle Details
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The authors declare that they have no apparent or potential conflicts of interest related to the publication of this article.
This work is licensed under a Creative Commons Attribution 4.0 License.
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References
Rasporyazhenie Pravitel`stva Rossijskoj Federacii ot 29 dekabrya 2022 g. № 4356-r Nacional`naya strategiya dejstvij v interesax zhenshhin 2023-2030 gody`, Moskva. Russian (Распоряжение Правительства Российской Федерации от 29 декабря 2022 г. № 4356-р Национальная стратегия действий в интересах женщин 2023-2030 годы, Москва.) https://www.garant.ru/products/ipo/prime/doc/405965441/ (дата обращения 27.09.2024)
Apolihin OI, Pushkar` DYu, Gvasaliya BR, Korneev IA, Krasnyak SS, Kamkin EG, i dr. Metodicheskie rekomendacii po dispanserizacii muzhchin i zhenshhin reproduktivnogo vozrasta s cel`yu ocenki reproduktivnogo zdorov`ya. Russian (Аполихин О.И., Пушкарь Д.Ю., Гвасалия Б.Р., Корнеев И.А., Красняк С.С., Камкин Е.Г., и др. Методические рекомендации по диспансеризации мужчин и женщин репродуктивного возраста с целью оценки репродуктивного здоровья.) https://www.garant.ru/products/ipo/prime/doc/408788357/ (дата обращения 27.09.2024)
Zhenskoe besplodie. Klinicheskie rekomendacii. ID: 641 Moskva, 2021. 78 s. Russian (Женское бесплодие. Клинические рекомендации. ID: 641 Москва, 2021. 78 с.) https://cr.minzdrav.gov.ru/recomend/641_1 (дата обращения 27.09.2024)
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, et al. Bisphenol A: an emerging threat to female fertility. Reprod Biol Endocrinol. 2020; 18(1): 22. doi: 10.1186/s12958-019-0558-8
Ennab F, Atiomo W. Obesity and female infertility. Best Pract Res Clin Obstet Gynaecol. 2023; 89: 102336. doi: 10.1016/j.bpobgyn.2023.102336
Shubham S, Kumar M, Singh K. Female infertility: dietary effects, effect of stress, chemical or toxicant, environment, stds, sexual violence. Int J Creat Research Thoughts. 2022; 10(6): 123-143
Frolova NI. Osnovny`e prediktory` i konfaundery` reproduktivny`x narushenij u zhenshhin rannego fertil`nogo vozrasta: Avtoref. dis. … dokt. med. nauk. Chita, 2020. 53 s. Russian (Фролова Н.И. Основные предикторы и конфаундеры репродуктивных нарушений у женщин раннего фертильного возраста: Автореф. дис. … докт. мед. наук. Чита, 2020. 53 с.)
Belokrinitskaya TE, Liga VF, Kargina RN, Frolova NI. Reproductive medicine in the light of demographic trends in modern Russia. Versions and contraversions of modern gynecology and reproductive medicine: Mater. of the All-Russian scient. and pract. conf. of obstet. and gynecol.. Chita State Medical Academy, 2018. P. 6-8. Russian (Белокриницкая Т.Е., Лига В.Ф., Каргина Р.Н., Фролова Н.И. Репродуктивная медицина в свете демографических тенденций в современной России //Версии и контраверсии современной гинекологии и репродуктивной медицины: Материалы Всероссийской научно-практической конференции акушеров-гинекологов. Читинская государственная медицинская академия, 2018. С. 6-8)
Bala R, Singh V, Rajender S, Singh K. Environment, Lifestyle, and Female Infertility. Reprod Sci. 2021; 28(3): 617-638. doi: 10.1007/s43032-020-00279-3
Shingshetty L, Cameron NJ, Mclernon DJ, Bhattacharya S. Predictors of success after in vitro fertilization. Fertil Steril. 2024; 121(5): 742-751. doi: 10.1016/j.fertnstert.2024.03.003
Zhao J, Wang R, Song L, Han H, Wang P, Zhao Y, et al. Causal association between lipid-lowering drugs and female reproductive endocrine diseases: a drug-targeted Mendelian randomization study. Front Endocrinol. 2023; 14: 1295412. doi: 10.3389/fendo.2023.1295412
Bhardwaj JK, Bikal P, Sachdeva SN. Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies. J Biochem Mol Toxicol. 2023; 37(7): e23371. doi: 10.1002/jbt.23371
Spears N, Lopes F, Stefansdottir A, Rossi V, De Felici M, Anderson RA, Klinger FG. Ovarian damage from chemotherapy and current approaches to its protection. Hum Reprod Update. 2019; 25(6): 673-693. doi: 10.1093/humupd/dmz027
de Angelis C, Nardone A, Garifalos F, Pivonello C, Sansone A, Conforti A, et al. Smoke, alcohol and drug addiction and female fertility. Reprod Biol Endocrinol. 2020; 18(1): 21. doi: 10.1186/s12958-020-0567-7
He S, Wan L. Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years. Front Endocrinol (Lausanne). 2023; 14: 1140739. doi: 10.3389/fendo.2023.1140739
Hernáez Á, Wootton RE, Page CM, Skåra KH, Fraser A, Rogne T, et al. Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Fertil Steril. 2022; 118(1): 180-190. doi: 10.1016/j.fertnstert.2022.04.001
Bu FL, Feng X, Yang XY, Ren J, Cao HJ. Relationship between caffeine intake and infertility: a systematic review of controlled clinical studies. BMC Womens Health. 2020; 20(1) 125. doi:10.1186/s12905-020-00973-z
Purdue-Smithe AC, Kim K, Schliep KC, DeVilbiss EA, Hinkle SN, Ye A, et al. Preconception caffeine metabolites, caffeinated beverage intake, and fecundability. Am J Clin Nutr. 2022; 115(4): 1227-1236. doi: 10.1093/ajcn/nqab435
Oldfield AL, Carter FE, Reeves RE, Jarrett BY, Vanden Brink H, Lujan ME. Impact of a hypocaloric dietary intervention on antral follicle dynamics in eumenorrheic women with obesity. Hum Reprod. 2024; 39(4): 801-811. doi: 10.1093/humrep/deae017
Farland LV, Pollack AZ, Schliep KC. Studying reproductive and gynaecologic health as risk factors for chronic disease development. Paediatr Perinat Epidemiol. 2024; 38(4): 343-344. doi: 10.1111/ppe.13041
Yin YH, Zhou SY, Lu DF, Chen XP, Liu B, Lu S, et al. Higher waist circumference is associated with increased likelihood of female infertility: NHANES 2017-2020 results. Front Endocrinol (Lausanne). 2023; 14: 1216413. doi: 10.3389/fendo.2023.1216413
Weiss MC, Wang L, Sargis RM. Hormonal Injustice: Environmental Toxicants as Drivers of Endocrine Health Disparities. Endocrinol Metab Clin North Am. 2023; 52(4): 719-736. doi: 10.1016/j.ecl.2023.05.009
Dalamaga M, Kounatidis D, Tsilingiris D, Vallianou NG, Karampela I, Psallida S, Papavassiliou AG. The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies. Int J Mol Sci. 2024; 25(1): 675. doi: 10.3390/ijms25010675
Chaichian S, Khodabandehloo F, Haghighi L, Govahi A, Mehdizadeh M, Ajdary M, Varma RS. Toxicological Impact of Bisphenol A on Females' Reproductive System: Review Based on Experimental and Epidemiological Studies. Reprod Sci. 2024; 31(7): 1781-1799. doi: 10.1007/s43032-024-01521-y
Zhu X, Liu M, Dong R, Gao L, Hu J, Zhang X, et al. Mechanism Exploration of Environmental Pollutants on Premature Ovarian Insufficiency: a Systematic Review and Meta-analysis. Reprod Sci. 2024; 31(1): 99-106. doi: 10.1007/s43032-023-01326-5